Salvo

Description

SALVO ADVANCED TRANSDERMAL CARRIER SYSTEM
(CURRENT SOLUTION)

Salvo is the most advanced current solution on the market. It allows for very highly concentrated solutions and contains the most effective topical skin permeation enhancers commercially available.
By purchasing powders in bulk and using Salvo’s advanced delivery matrix, athletes and bodybuilders can achieve excellent results.

SUSTAINED RELEASE
Passive diffusion through the layers of the dermis causes a time-delayed release, allowing sustained blood levels of the active ingredients and convenient once-daily dosing.

Increased bioavailability
Increased bioavailability by avoiding the first-pass effect of liver metabolism may be a clear advantage of topical administration – particularly for active, non-17a-methylated hormones.

ACTIVITY AMPLIFIER
The intercellular lipids of the stratum corneum are considered the main obstacle to the permeation of lipophilic compounds. Salve contains potent ingredients that modulate this lipid matrix and influence the non-polar route to improve permeation. These ingredients include thiazone, which is 3-12 times more potent than ozone as a permeation enhancer for lipophilic molecules, and nerolidol, a lipophilic terpene that has been shown to greatly facilitate the delivery of lipophilic molecules. It also includes oleic acid and stearyl methacrylate, fatty acid derivatives that insert between the hydrocarbon tails of the intercellular stratum corneum lipids, thereby disrupting lipid packing, increasing fluidity and promoting diffusion through the outer layer of the stratum corneum.

SUPERSATURATION
Salvo uses a volatile:non-volatile co-solvent vehicle to create a supersaturation state that helps compounds cross the outer layers of the stratum corneum. As the volatile component evaporates on your skin, the solution becomes more concentrated and eventually becomes supersaturated, resulting in increased thermodynamic pressure and improved penetration.

TECHNICAL ADVICE
Salvo is generally compatible with active ingredients that have LogP values of 1.5 to 4.0. Designed for use with lipophilic ingredients, Salvo’s system does not affect the polar pathway of stratum corneum permeation and therefore compounds with lower lipophilicity are not adequately distributed into the SC lipids. Compounds with LogP values above 4.0 may have such a high affinity for the same SC lipids that they accumulate there and do not reach the lower levels of the epidermis in appropriate concentrations.
Molecular weight is a good indicator of chemical surface area, which is directly related to the diffusion coefficient. Therefore, compounds with a MW > 500 work well in this topical system.
The melting point is an indicator of solubility in skin lipids. In general, compounds with low melting points are more compatible with topical solutions than compounds with high melting points. -Ionized species will penetrate less easily than free acid forms.